- Nov 18, 2018
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Well, he uses the term "LDL cholesterol", which does not exist. LDL is a lipoprotein carrier of cholesterol. However, such a common mistake can be forgiven when its a "common speech" youtube format having 8 minutes.Yes! Science is finding that it's not the whole package of LDL cholesterol but the LPa part. My medical doctor on YouTube has made me healthier.
What about the Randle Cycle? Carbohydrates and fats compete for energy processing in cells (and the combination of fats and carbohydrates in meals is basically non-existent in natural food, its a modern thing).
I deleted my post about the Randle cycle and created a specific thread, instead. Because its a bit a different topic for this thread which is more about cholesterol. You probably still had it in your browser's cache.Exercising in fasted state and eating with restraint (as opposed to indulgence) would prevent problems you could have with high fat and high carb diet.
Animals who are very physically active like birds and bats also live on diets that combine high fat and high carbs. High-fat insects and high carb fruits are staple food for many species of omnivorous birds and bats. It's not a problem if energy demand is high.
Everyday, I do 1 hr of running with 1,000 ft of elevation gain. On Saturdays, it can be nearly 6 hrs nonstop cycling ride with 5,500 elevation gain in the mountains. I do these workouts without eating nor drinking without any problems. An impossible thing to do if your metabolism and mitochondria is impaired.
I didn't know about the Randle thing until you told me. The Holy Spirit is wise above all else. Holy Spirit told me many things to stay healthy but two things stood out which is exercise and fasting and combining those two - exercising in fasted state.
Flooding the system with glucose on top of fatty acids is expected to induce considerable damage to the mitochondria if energy demand is not concomitantly increased. An overabundant diet rich in carbohydrates and fat (184) should force-feed electrons from glucose into the respiratory chain, in which the already prevailing high ΔΨ prevents electron flow. This excessive energy supply, not matched by energy demand, will further worsen the jamming of electrons in the respiratory chain and eventually result in massive ROS production and mitochondrial damage (Fig. 7). In addition, a saturated flux through the glycolytic pathway could result in an overflow into the hexosamine biosynthetic pathway leading to protein glycosylation by O-linked β-N-acetylglucosamine (67, 106, 192). The persistent combination of these two effects probably explains glucose toxicity. By contrast, the beneficial effects of physical activity and muscle exercise could prevent mitochondrial damage by decreasing ΔΨ and favoring the overall oxidation of substrates to fulfill the increased energy demand.
The Randle cycle revisited: a new head for an old hat
In 1963, Lancet published a paper by Randle et al. that proposed a “glucose-fatty acid cycle” to describe fuel flux between and fuel selection by tissues. The original biochemical mechanism explained the inhibition of glucose oxidation ...www.ncbi.nlm.nih.gov
Yes, exercise is key to longevity. Lean muscle mass is extremely important as you age because that our glucose storage organ.that if you exercise
I agree that some kind of a movement is important, together with lean muscle mass.Yes, exercise is key to longevity. Lean muscle mass is extremely important as you age because that our glucose storage organ.
It will take more than just movement. As we age, we lose muscle, so protein intake and exercise are very important for geriatrics, and it helps structural support. Saturated fats should be kept to a minimum. I quite taking my statins because of the misconceptions about LDL cholesterol. Science has found that LP(a) is the culprit to heart health. PeaceI agree that some kind of a movement is important, together with lean muscle mass.
I guess you are right that if you exercise a lot, you may mitigate some of the problems with the Randle cycle.
I agree that some kind of a movement is important, together with lean muscle mass.
Regarding glucose - our body can produce its own glucose (gluconeogenesis) and to cover all the needs, mainly for brain. Any gram of glucose we eat in our diet goes on the top of that and becomes potentially toxic for our body, so it needs to deal with it as fast as possible (to use it as a priority for energy or to transform it to fat).
How many days per week?intermittent fasting
Epidemiological studies are a dead science. The life of individuals outside of controlled conditions is so unpredictable, that these statistical findings can have no clinical practice impacts.atherosclerosis is widespread in populations with high intake of saturated fat.
Epidemiological studies are a dead science.
Nope. It actually is not even based on epidemiology. When the epidemiologic studies are done right, without data cherrypicking or manipulation, there is no significant correlation between saturated fats and any CVD.The evidence for saturated fat causing atherosclerosis is based on more than just epidemiology.
Observational studies are more a sociology than for establishing health guidelines. Using it for recommendations what to do or what to eat is a dead and lazy science.Having said, that the notion that epidemiology is "dead science" is just flat out wrong. Epidemiology has been an important part of many public health advances in the 20th century.
It's damage to the arteries is the cause and cholesterol is the reaction of the inflammatory response. Then fats exasperate the problem through buildup onto the cholesterol.saturated fat causing atherosclerosis
What causes the initial damage to the arterial walls, though? I was able to google smoking, but the rest seems quite vague, like "lifestyle".It's damage to the arteries is the cause and cholesterol is the reaction of the inflammatory response. Then fats exasperate the problem through buildup onto the cholesterol.
What causes atherosclerosis?
Plaque buildup in the arteries starts with damage to the arteries. Risk factors such as unhealthy lifestyle habits, medical conditions, or your genes, can lead to this damage.
Causes and Risk Factors
www.nhlbi.nih.gov
The article says metabolic diseases High blood pressure diabetes. The lining of the arteries is smooth but when a micro fracture happens then cholesterol acts as a banda aid then stuff fats in the blood stream starts to build up from my understanding.What causes the initial damage to the arteries walls, though? I was able to google smoking, but the rest seems quite vague, like "lifestyle".
Ah, yes, high blood pressure makes sense.The article says metabolic diseases High blood pressure diabetes. The lining of the arteries is smooth but when a micro fracture happens then cholesterol acts as a banda aid then stuff fats in the blood stream starts to build up from my understanding.