C 15 Nutrient Deficiency

[timewerx]

I never claimed it is. I only said to a specific person in this thread to try to eliminate it and to see if it helps. And just because he mentioned it.

There's no way I would have thought you're talking about another CF member in this thread from your reply to my post. Here's what you wrote originally when you quoted my post (post #12):

Check for example Jordan Peterson or his daughter Mikhaila Peterson. Search for IBS and similar, you will find many other examples. I have also problem with fiber, even in small amounts.

You do not need to follow me like a white knight of the standard nutrition guidelines and fight for them whenever I recommend to try something different.

I wasn't entirely disagreeing with your posts. I'm meeting you half-way, even saying what you say is true in some circumstances in the proper context.

When someone is having problems with their health, you're quick to point out it's vegetables and fruits and fiber and say nothing good about the food group when there are many other possible reasons why someone is having health issues. It can be misleading without the proper context. It can cause one to overlook the real cause of their issues or avoid things they do need. Context is everything.

 

[FireDragon76]

Check for example Jordan Peterson or his daughter Mikhaila Peterson. Search for IBS and similar, you will find many other examples. I have also problem with fiber, even in small amounts.

I was diagnosed with IBS back in my 30's. Just because you have been diagnosed with IBS, doesn't mean you should necessarily avoid fiber for the rest of your life.

 

[timewerx]

I was diagnosed with IBS back in my 30's. Just because you have been diagnosed with IBS, doesn't mean you should necessarily avoid fiber for the rest of your life.

I had bouts of IBS whenever I consumed more food than needed by my body.

I only became conscious of it last year and it's gone completely by this year even if on some occasions I indulge on food because relatives came over and brought lots of food with them.

Another factor is quitting the habit of drinking (any beverage including water) while eating and even shortly before a meal. Water will dilute the acid in the stomach and result to poor digestion.

Some "old" outdated weight loss strategy is to drink water while eating to hasten the feeling of "fullness" or satiety to aid in reducing calorie intake but has the negative effect in digestion and can make you feel hungry too soon after a meal.

 

[trophy33]

I was diagnosed with IBS back in my 30's. Just because you have been diagnosed with IBS, doesn't mean you should necessarily avoid fiber for the rest of your life.

"For the rest of your life" is a bit exaggerated. Who wants, can experiment with adding plants into their diet, who does not want, does not have to.

 

[FireDragon76]

I had bouts of IBS whenever I consumed more food than needed by my body.

IBS isn't indigestion, which affects the stomach.

IBS is disregulation in the motility of the intestines, either too fast or too slow. Bacterial dysbiosis is commonly associated with IBS, and may contribute to the condition, but it can have many contributing factors, such as diseases that affect the nervous system (diabetic neuropathy, fibromyalgia, etc.).

 

[timewerx]

IBS isn't indigestion, which affects the stomach.

IBS is disregulation in the motility of the intestines, either too fast or too slow. Bacterial dysbiosis is commonly associated with IBS, and may contribute to the condition, but it can have many contributing factors, such as diseases that affect the nervous system nervous system (diabetic neuropathy, fibromyalgia, etc.).

That's true and I really did have IBS from childhood lasting until two years ago and completely disappearing this year.

It did start at the same time I suffered brain damage from play injury, hitting my head hard on a metal beam.

I did not pass waste normally as everybody else and it's an embarrassing problem I dealt in a daily basis. Until I started exercising couple of years ago, it then became periodic, only if I ate too much calories. And then with intermittent fasting and calorie restriction that began last year, it's gone completely this year.

 

[Laodicean60]

The only peer reviewed study claiming that C15 is essential for health is one that is funded by a company promoting C15

The hypothesis is that C15 should be an essential amino acid. I'm not sure where you looked but I suggest Google Scholar "health benefits Pentadecanoic acid" There are tons of peer-reviewed studies on this fat.

Study shows C15:0 more effective than ‘fountain of youth’ alternatives

Mounting evidence shows that Pentadecanoic acid, or C15:0, an essential fatty acid, is as beneficial as anti-aging drug rapamycin, including sharing anti-inflammatory, anticancer, antifibrotic and antimicrobial activities, according to research published in Nutrients.

www.nutraingredients-usa.com

"Funding
This work was funded in part by the Office of Naval Research (Agreement No. N00014-2109-0002); NJS data analysis efforts are supported in part by NIH grants U19 AG023122, UH3 AG064706, U19 AG065169."

Pentadecanoic Acid, an Odd-Chain Fatty Acid, Suppresses the Stemness of MCF-7/SC Human Breast Cancer Stem-Like Cells through JAK2/STAT3 Signaling

Saturated fatty acids possess few health benefits compared to unsaturated fatty acids. However, increasing experimental evidence demonstrates the nutritionally beneficial role of odd-chain saturated fatty acids in human health. In this study, the anti-cancer effects of pentadecanoic acid were...

www.mdpi.com

Funding
This research was funded by the National Research Foundation of Korea (NRF) grant number 2020R1A2C1004349.

Conflicts of Interest
The authors declare no conflict of interest.

I did and I also looked up C15 for peer-reviewed studies saying it only existed in trace amounts in dairy to even matter in nutrition.

Lol, that's why so many people are deficient, did your information mention the homogenization process? Please post your information, not your thoughts. These studies are relatively new and this information is for anyone who has a family member who has metabolic syndrome, of course, everyone should do their due diligence.

 

[Laodicean60]

Fiber can actually cause or add to your "health problems increasing the whole life". Many people have problems with fiber.

Your gut needs fiber from all that I've read but if you have info to the contrary please post I'll read it.

 

[trophy33]

Your gut needs fiber from all that I've read but if you have info to the contrary please post I'll read it.

We live in a total chaos regarding nutrition science. Much religion, bias, corporate interest and low-quality, useless or contradictory research is involved. Thats why I would recommend you to simply try it for few weeks or months and see if it works for you. But do not forget to eat enough fat, to have a sufficient bowel movement.

But if you want some source, then for example:

 

[FireDragon76]

Your gut needs fiber from all that I've read but if you have info to the contrary please post I'll read it.

The fiber that your gut bacteria use to produce short chain fatty acids are soluble fibers. Insoluble fiber doesn't really ferment in the human gut.

 

[Laodicean60]

We live in a total chaos regarding nutrition science. Much religion, bias, corporate interest and low-quality, useless or contradictory research is involved. Thats why I would recommend you to simply try it for few weeks or months and see if it works for you. But do not forget to eat enough fat, to have a sufficient bowel movement.

But if you want some source, then for example:

The paper he cited was from 2008 is there any newer info? The nice thing about Google Scholar you can filter papers by year. Still, most papers give a positive review and I'm sure you've heard about pre and pro-biotics benefits to the gut microbiome.

 

[trophy33]

The paper he cited was from 2008 is there any newer info? The nice thing about Google Scholar you can filter papers by year. Still, most papers give a positive review and I'm sure you've heard about pre and pro-biotics benefits to the gut microbiome.

I stopped searching for papers. The problem with papers about nutrition is that most of them are totally useless. Its a junk science, in most cases and contradictory in other cases.

I would again repeat that its best to simply try it for few weeks or months and see if you get better. No paper on google scholar will tell you that. If the government guidelines do not help you with your deteriorating health, it may be time to think out of the box/common narrative.

 

[Laodicean60]

The problem with papers about nutrition is that most of them are totally useless. Its a junk science, in most cases.

The video you posted doc cited a paper so do you have another recent paper saying the same that you feel isn't junk science? Unless you are saying researchers around the world are conspiring to promote junk science.

 

[trophy33]

The video you posted doc cited a paper so do you have another recent paper saying the same that you feel isn't junk science? Unless you are saying researchers around the world are conspiring to promote junk science.

Its your health. I gave you a tip, but if you will try it or not is on you.

The quality of your microbiome is caused by the health of your mother during pregnancy, by breastfeeding, not using antibiotics, not drinking alcohol and not eating foods with various industrial chemicals. The rest is not too influential. If you want to support your microbiome after some illness, you can use some fermented food.

 

[Laodicean60]

You will not be healthy without actually trying/changing things.

I started Keto around Covid and used it to lose a ton of weight and I remember being constipated. The Atkins diet was worse as far as constipation back in 2000. With Keto, I lost weight and my A1C went from 7.9 to 6.2. Now I eat a balanced diet everything that God has placed on this earth for us to consume.

Anyway, its your health. I gave you a tip, but if you will try it or not is on you. The quality of your microbiome is caused by the health of your mother, not using antibiotics and not drinking alcohol. The rest is not too influential.

I don't need your tip because I am trying to read about health. True the mother introduces bacteria to the child but have you heard that eating different foods can diversify your gut bacteria? I will end it here because I'm OT again.

 

[trophy33]

have you heard that eating different foods can diversify your gut bacteria?

If you eat diverse food you will need diverse gut bacteria. If you eat for example only meat you will have meat-specialized gut bacteria. Its logical. If you believe more diverse is better for overall health as such, in your dietary context, then do it.

I started Keto around Covid and used it to lose a ton of weight and I remember being constipated. The Atkins diet was worse as far as constipation back in 2000. With Keto, I lost weight and my A1C went from 7.9 to 6.2. Now I eat a balanced diet everything that God has placed on this earth for us to consume.

Because you mentioned that your health is still getting worse, then something does not seem right, still. Maybe God did not give us everything on this planet to consume or the food we consume today is not given to us by God, but by industry or your individual body does not work well with specific foods. We evolved in specific areas with local foods, while we are supplied by all foreign types of food today.

 

[timewerx]

The hypothesis is that C15 should be an essential amino acid. I'm not sure where you looked but I suggest Google Scholar "health benefits Pentadecanoic acid" There are tons of peer-reviewed studies on this fat.

Study shows C15:0 more effective than ‘fountain of youth’ alternatives

Mounting evidence shows that Pentadecanoic acid, or C15:0, an essential fatty acid, is as beneficial as anti-aging drug rapamycin, including sharing anti-inflammatory, anticancer, antifibrotic and antimicrobial activities, according to research published in Nutrients.

www.nutraingredients-usa.com

This work was funded in part by the Office of Naval Research (Agreement No. N00014-2109-0002); NJS data analysis efforts are supported in part by NIH grants U19 AG023122, UH3 AG064706, U19 AG065169."

Conflicts of Interest
The authors declare no conflict of interest.

I found the peer reviewed study source of the link you shared above with exactly the same Office of Naval Research Agreement and it stated a conflict of interest:

Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds

Pentadecanoic acid (C15:0) is an essential odd-chain saturated fatty acid with broad activities relevant to protecting cardiometabolic, immune, and liver health. C15:0 activates AMPK and inhibits mTOR, both of which are core components of the human longevity pathway. To assess the potential for...

www.mdpi.com

Funding
This work was funded in part by the Office of Naval Research (Agreement No. N00014-2109-0002); NJS data analysis efforts are supported in part by NIH grants U19 AG023122, UH3 AG064706, U19 AG065169.

Author Contributions
Conceptualization, S.V.-W. (Stephanie K. Venn-Watson) and N.J.S methodology, S.V.-W. and N.J.S.; software, S.V.-W.; validation, S.V.-W. and N.J.S.; formal analysis, S.V.-W. and N.J.S.; investigation, S.V.-W. and N.J.S.; resources, S.V.-W. and N.J.S.; data curation, S.V.-W.; writing—original draft preparation, S.V.-W. and N.J.S.; writing—review and editing, S.V.-W. and N.J.S.; visualization, S.V.-W.; supervision, S.V.-W.; project administration, S.V.-W.; funding acquisition, S.V.-W. All authors have read and agreed to the published version of the manuscript.

Conflicts of Interest​

S.V.-W. (Stephanie K. Venn-Watson) is a co-founder of and employed by Epitracker, Inc and Seraphina Therapeutics, Inc, which hold exclusive licensing rights from the U.S. Navy to commercialize odd-chain saturated fatty acids as human and animal health products. NJS is a co-founder of and consultant to Seraphina Therapeutics, Inc.

Here's another study by Stephanie K. Venn-Watson

Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems - PMC

A growing body of evidence supports that pentadecanoic acid (C15:0), an odd-chain saturated fat found in butter, is an essential fatty acid that is necessary in the diet to support long-term metabolic and heart health. Here, dose dependent and ...

www.ncbi.nlm.nih.gov

Funding Statement​

This work was funded by the Office of Naval Research (SBIR Award No. N6833518C0746, www.onr.navy.mil) received by SV and Epitracker, Inc. (www.epitracker.com). SV (Stephanie K. Venn-Watson) receives salary from Epitracker, Inc. and Seraphina Therapeutics, Inc. The funders, other than the named authors, had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

https://www.linkedin.com/in/stephanievennwatson

Another article by Stephanie K. Venn-Watson

Studies Helping Older Dolphins Reveal the Anti-Aging Potential of Fatty15

Groundbreaking research by veterinarians helping dolphins uncovers the anti-aging benefits of Fatty15. Explore how this unique fatty acid promotes longevity and health.

connect.gdx.net

Apparently, these articles are based on studies made by people who founded a company who plans to sell C15. Even if they're 100% legit, the circumstances these studies are made greatly increase the chance of biased analysis/reports.

The claimed effects of C15 like autophagy, reduced inflammation, activation of AMPK, inhibition of mTOR, etc.

Is exactly the same thing that fasting achieves.

But I'd rather go with fasting because it's time tested and proven.

 

[trophy33]

I don't need your tip because I am trying to read about health

It may be more effective to listen to doctors who have their own practice and see daily what helps people to get healthy. Reading studies by yourself is very difficult and too theoretical.

Luckily, there are many good ones out there, sharing their knowledge.

 

[Laodicean60]

Apparently, these articles are based on studies made by people who founded a company who plans to sell C15.

The ones you posted sure but aren't there others?

The claimed effects of C15 like autophagy, reduced inflammation, activation of AMPK, inhibition of mTOR, etc.

Is exactly the same thing that fasting achieves.

You left out premature cell death which might be causing kids to get sick. I fast and fasting isn't for everyone. I'll let science tell me if C15 should be added to the list of essential amino acids.

 

[timewerx]

The ones you posted sure but aren't there others?

One of those links originally came from you.

When using search keywords "Pentadecanoic Acid", the only search results claiming it's an essential nutrition are from Stephanie K. Venn-Watson who is a founder of a company selling C15 supplements. At least one of them is an article promoting her company.

Another link I found saying positive things about C15 is a Korean study concerning its positive effect on breast cancer. I think it's one of the links you shared earlier. However, the study isn't about the role of C15 on overall health but only its effect on breast cancer. It did not make any recommendations about C15 concerning nutrition nor overall health.

Other links are simply displaying chemical information about the compound. Many others are links selling C15 supplements by Stephanie K. Venn-Watson's company (Seraphina Therapeutics) and at least one is saying they can't find any association of C15 with metabolic disease.

See for yourself:

Pentadecanoic Acid - Google Search

www.google.com

It seems that we simply cannot trust the information that is available at the moment that is saying that C15 is essential nutrition.

Because the most comprehensive study done on C15 and its effect on overall human health is made by individuals who are selling C15 and because sources that are not involved with Dr. Stephanie K. Venn-Watson nor her company in any way are not making the same claims about C15.

That's a major conflict of interest and trust issue. But if you can find anything to disprove any doubts, just keep posting those links.

You left out premature cell death which might be causing kids to get sick. I fast and fasting isn't for everyone. I'll let science tell me if C15 should be added to the list of essential amino acids.

I mentioned "autophagy" back there. Autophagy is programmed cell death like Apoptosis. Fasting also induces apoptosis.

Programmed cell death helps prevents premature cell death.

I fast and fasting isn't for everyone.

That is true but most people can do intermittent fasting instead. You can replicate the effects of a longer fast with intermittent fasting by exercising during the "fasting window"