C 15 Nutrient Deficiency

[Laodicean60]

When using search keywords "Pentadecanoic Acid", the only search results claiming it's an essential nutrition are from Stephanie K. Venn-Watson who is a founder of a company selling C15 supplements. At least one of them is an article promoting her company.

Her original research was on dolphins and she was curious about humans and found the deficiency but I'll let the science play out. If she makes a dime I don't care as long as the science is sound and at least for the navy dolphins they are getting healthy because of her research.

Fasting

This topic isn't about the lifestyle it's about nutrients.

It seems that we simply cannot trust the information that is available at the moment that is saying that C15 is essential nutrition.

Fire and I said that the research is new and time will tell. You keep doing what you do but if this helps someone else good for them.

Because the most comprehensive study done on C15 and its effect on overall human health is made by individuals who are selling C15 and because sources that are not involved with Dr. Stephanie K. Venn-Watson nor her company in any way are not making the same claims about C15.

Well duh, she is the one who identified this deficiency in dolphins as she said in the video that researchers around the world are looking into this. So of course she'll have the most information about this subject.

I mentioned "autophagy" back there. Autophagy is programmed cell death like Apoptosis. Fasting also induces apoptosis.

Programmed cell death helps prevents premature cell death.

The key word was "premature" cell death.

 

[FireDragon76]

I think this looks much more promising in humans (not dolphins), give the role of gut microbiota in producing short-chain fatty acids, and the wider evidence base for positive health effects from consumption:

Human milk oligosaccharide - Wikipedia

en.wikipedia.org

HMO's used in commercial prebiotics aren't actually derived from human milk, they are synthesized.

 

[Laodicean60]

I think this looks much more promising in humans (not dolphins), give the role of gut microbiota in producing short-chain fatty acids, and the wider evidence base for positive health effects from consumption:

Human milk oligosaccharide - Wikipedia

en.wikipedia.org

HMO's used in commercial prebiotics aren't actually derived from human milk, they are synthesized.

Interesting, I am a firm believer in breastfeeding infants. I believe our health is affected by gut health this is why we should be feeding the gut with fiber from whole foods. The body doesn't produce pentadecanoic acid which is primarily from diet but your article is another add-on to the problems humans trying to replicate nature.

 

[timewerx]

she said in the video that researchers around the world are looking into this

Apart from herself and anyone else affiliate with her company, C15 is receiving little attention from other researchers.

Exercise still provides more benefits than C15 concerning longevity, anti-aging, cancer-prevention, etc. C15 on the other hand is quite expensive and you still need to exercise even if you already take C15 supplements (assuming the claimed health benefits are legit) to have well-rounded care for your health.

The key word was "premature" cell death.

I read it right the first time that's why I said that "premature" cell death is mitigated by "programmed" cell death from autophagy and apoptosis.

 

[Laodicean60]

Exercise still provides more benefits than C15 concerning longevity, anti-aging, cancer-prevention, etc. C15 on the other hand is quite expensive and you still need to exercise even if you already take C15 supplements (assuming the claimed health benefits are legit) to have well-rounded care for your health.

Again this thread is about a possible nutrient deficiency, not lifestyle we all know about the other benefits.

I read it right the first time that's why I said that "premature" cell death is mitigated by "programmed" cell death from autophagy and apoptosis.

Yes but if the lack of nutrients is causing premature cell death then you have a problem.
Autophagy is great for cleaning and recycling damaged or aged cells. When you prolong fast autophagy captures nutrients or after you exercise it takes care of torn muscle tissue. It also eats cancerous cells.

 

[timewerx]

Again this thread is about a possible nutrient deficiency, not lifestyle we all know about the other benefits.

I thought you might appreciate me sharing alternatives that replicates the claimed health benefits of C15.

Because current research claiming C15 is an essential nutrient is not trustworthy (with huge conflict of interest).

Yes but if the lack of nutrients is causing premature cell death then you have a problem.

So far there is no trustworthy research proving it's due to lack of C15.

Look, I'd like to make myself clear I'm not saying C15 is all bad. There maybe a market for it, maybe even help cure some disease or alleviate symptoms of some genetic disorders. Just the claim of it being essential nutrient, there is simply the absence of trustworthy information.

The presence of conflict of interest is a strong signal for some to look for other sources of information with zero relation to research with conflicts of interest.

 

[Laodicean60]

Because current research claiming C15 is an essential nutrient is not trustworthy (with huge conflict of interest).

The presence of conflict of interest is a strong signal for some to look for other sources of information with zero relation to research with conflicts of interest.

I don't think you took my advice and looked at C15 using Google Scholar. What was felt about long-chain FA isn't true after all now scientists are studying the effects. There are many research articles on C15 and other OCFA's and your biases will keep you uninformed. And maybe Stephanie K. Venn-Watson research opened people's eyes to the benefits of odd-chain fatty acids. I will end our conversation. Peace

3 of many independent studies.

A Review of Odd-Chain Fatty Acid Metabolism and the Role of Pentadecanoic Acid (C15:0) and Heptadecanoic Acid (C17:0) in Health and Disease

The role of C17:0 and C15:0 in human health has recently been reinforced following a number of important biological and nutritional observations. Historically, odd chain saturated fatty acids (OCS-FAs) were used as internal standards in GC-MS methods of total fatty acids and LC-MS methods of...

www.mdpi.com

Different large scale epidemiological studies have now shown that the plasma OCS-FAs levels are associated with reduced disease risks for CHD [12,74,88,89] and T2D [27,90]. These studies contradict the original ideas around OCS-FAs being insignificant in comparison to even chain fatty acids.

Pentadecanoic acid promotes basal and insulin-stimulated glucose uptake in C2C12 myotubes

Saturated fatty acids (SFAs) generally have been thought to worsen insulin-resistance and increase the risk of developing type 2 diabetes mellitus (T2DM). Recently, accumulating evidence has revealed that SFAs are not a single homogeneous group, instead ...

www.ncbi.nlm.nih.gov

PA, an odd-chain SFA, significantly stimulates glucose uptake via the AMPK-AS160 pathway and exhibits an insulin-sensitizing effect in myotubes.

Fatty acids in non-alcoholic steatohepatitis: Focus on pentadecanoic acid

Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and ranges from isolated steatosis to NASH. To determine whether circulating fatty acids could serve as diagnostic markers of NAFLD severity and whether specific fatty acids could contribute to the pathogenesis of...

journals.plos.org

The ratio 15:0 to 17:0 in our analysis was also 1:2. Recent studies suggested that bio-synthesis of odd chain fatty acids can occur through alpha-oxidation in adipose tissue. Both 15:0 and 17:0 have been shown to have a positive association with health and in particular with risk for type 2 diabetes and cardiovascular diseases.[35, 37–39]

https://bookcafe.yuntsg.com/ueditor/jsp/upload/file/20231219/1702949493438061474.pdf

Mediterranean like diet intervention groups was greater than in the control group,
together with greater reductions in some metabolic risk factors (total
cholesterol and triglyceride concentrations). C15:0 supplementation
caused a further reduction in LDL-cholesterol compared with no supplementation.

 

[timewerx]

I will end our conversation. Peace

I feel disappointed by the abrupt end to our conversation when I'm actually agreeing with the latest links you shared within its context.

But I have no friends in real life so this is not your fault. Peace to you too.