If past similar protests on other topics are any indicator, not all that well.
I've yet to see any meaningful climate regulations come out of people throwing soup on paintings and blocking roads for that, and we didn't see any meaningful banking regulations coming out of the Occupy protests when they were blocking roads and areas of cities for that.
To your latter part, I can see that being valid for "under the radar issues" that most people have never heard of.
But what we see most of these types of protests for now are issues that are amply covered at a national level, and not only covered, but issues for which the overwhelming majority has already picked their side, and there's nothing to gain and everything to lose.
Sort of like with the "Just Stop Oil" protestors...everyone was already aware of the climate change debate, everyone's pretty much picked which side they're on (so they aren't picking up any converts with their antics), and defacing art in an art museum (which is already a more left leaning crowd who were likely already on their side) does nothing but risking actually losing support.
This particular event in question sort of has the same vibe. A progressive protest, inconveniencing and annoying a bunch of people in San Francisco
(a city that's overwhelmingly Blue)
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...means that they're agitating a bunch of people who were likely already on their side in the first place, so they likely aren't making any new friends, just enemies.
As a more generalized stance on these types of protests, I think the line gets drawn at the place where you're preventing people from being able to use the publicly funded services/infrastructure for the purpose for which it was intended, and which they paid taxes for. If I lived there, I'd be quite upset. Given their high rates of taxation in Cali, if I'm paying taxes for the roads/bridges, I get to use them for transportation and emergency services...period. Anyone intentionally prohibiting that is infringing on the rights of others. People shouldn't have to lose out on wages and potentially have emergency services disrupted just because some 20-something wants to post a cool "#SmashColonialism" story to post on their Instagram feed later...
The types of disorganized, disconnected leaderless movement rarely create any meaningful change, and quickly devolve into bunch of different people who want to signal their radicalness to everyone else "for the likes".