http://psycnet.apa.org/journals/szb/14/4/489/
The model is based on my assumptions as to the likely genetic abnormalities at possibly four or five interacting loci that would permit exorphins, the opioid peptides from some food proteins, especially glutens and possibly caseins, to go from gut to brain and cause symptoms of schizophrenia.
This model is supported by a variety of evidence, including a significant effect of gluten or its absence on relapsed schizophrenic patients, the high correlation of changes in first admission rates for schizophrenia with changes in grain consumption rates, and the rarity of cases of schizophrenia where grains and milk are rare
The gluten connection: the association between schizophrenia and celiac disease - Kalaydjian - 2005 - Acta Psychiatrica Scandinavica - Wiley Online Library
Based on initial findings, gluten withdrawal may serve as a safe and economical alternative for the reduction of symptoms in a subset of patients.
A drastic reduction, if not full remission, of schizophrenic symptoms after initiation of gluten withdrawal has been noted in a variety of studies. However, this occurs only in a subset of schizophrenic patients.
A COMPOSITION FOR LOWERING THE CONCENTRATION OF INTESTINAL PATHOGENIC PEPTIDES - Neurozym, Biotech AS
During the last year it has become clear that exorphins, a class of biologically active short peptides are produced enzymatically from gluten proteins in the gut during digestion. (Fukodome et al 1993, 1996, Froetshel 1996). These peptides, which are 4-5 amino acids long, have opioid activity and are relatively specific for δ-receptors.
DeSantis et al (1997) (DeSantis, A. et al (1997) Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet, Journal of internal medicine 242:421-423) has shown regression of schizophrenic symptoms and SPECT (Single Photon Computer Tomography) abnormalities in a celiac patient after a gluten-free diet. An involvement of gluten peptides in neurological diseases has recently been shown in celiac ataxia further supporting neuropathological effects of such substances (Hadjuvassilou et al 1998) (Hadjivassilou,M., Grunewald, R.A, Chattopadhyay,A.K et al (1998) Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia., The Lancet:352, 1582-1586) .
Accordingly, the findings of gluten derived exorphins in the urine of patients with schizophrenia; autism and mood disorders strongly suggest a causal relation, further supported by dietary experiments.
In conclusion, these investigations strongly support the idea that symptoms in such psychiatric disorders as schizophrenia, ADHD, autism and depressions, at least partly, result from incomplete breakdown and/or increased uptake of gut-derived peptides.
The model is based on my assumptions as to the likely genetic abnormalities at possibly four or five interacting loci that would permit exorphins, the opioid peptides from some food proteins, especially glutens and possibly caseins, to go from gut to brain and cause symptoms of schizophrenia.
This model is supported by a variety of evidence, including a significant effect of gluten or its absence on relapsed schizophrenic patients, the high correlation of changes in first admission rates for schizophrenia with changes in grain consumption rates, and the rarity of cases of schizophrenia where grains and milk are rare
The gluten connection: the association between schizophrenia and celiac disease - Kalaydjian - 2005 - Acta Psychiatrica Scandinavica - Wiley Online Library
Based on initial findings, gluten withdrawal may serve as a safe and economical alternative for the reduction of symptoms in a subset of patients.
A drastic reduction, if not full remission, of schizophrenic symptoms after initiation of gluten withdrawal has been noted in a variety of studies. However, this occurs only in a subset of schizophrenic patients.
A COMPOSITION FOR LOWERING THE CONCENTRATION OF INTESTINAL PATHOGENIC PEPTIDES - Neurozym, Biotech AS
During the last year it has become clear that exorphins, a class of biologically active short peptides are produced enzymatically from gluten proteins in the gut during digestion. (Fukodome et al 1993, 1996, Froetshel 1996). These peptides, which are 4-5 amino acids long, have opioid activity and are relatively specific for δ-receptors.
DeSantis et al (1997) (DeSantis, A. et al (1997) Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet, Journal of internal medicine 242:421-423) has shown regression of schizophrenic symptoms and SPECT (Single Photon Computer Tomography) abnormalities in a celiac patient after a gluten-free diet. An involvement of gluten peptides in neurological diseases has recently been shown in celiac ataxia further supporting neuropathological effects of such substances (Hadjuvassilou et al 1998) (Hadjivassilou,M., Grunewald, R.A, Chattopadhyay,A.K et al (1998) Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia., The Lancet:352, 1582-1586) .
Accordingly, the findings of gluten derived exorphins in the urine of patients with schizophrenia; autism and mood disorders strongly suggest a causal relation, further supported by dietary experiments.
In conclusion, these investigations strongly support the idea that symptoms in such psychiatric disorders as schizophrenia, ADHD, autism and depressions, at least partly, result from incomplete breakdown and/or increased uptake of gut-derived peptides.
