You seem to be a fan. So go ahead
Jim Tour is rather better at it than I am. If you want the short version............
Cells are vastly more complex structures than Darwin and other scientists imagined
The full range of precursor chemicals for life to form do not exist in nature
Chemicals can be formed, but not in the exact same composition as required by simple cells
Even if the exact chemicals were available, there is no mechanism for those chemicals to form something that is alive
Researchers use chemicals that they buy, lab quality and use controlled conditions.
Cells require carbohydrates. Carbohydrates caramelise with time. The time scales envisaged by OOL researchers are far too long for carbohydrates to survive.
Not to mention the problem of chirality.
In the same time that OOL research has been going on, the "H" bomb was invented, Jet aircraft became commonplace, computers shrank from room size to desktop, we have GPS navigation, men walked on the moon, there is a laboratory in space, solar panels, wind turbines, wave generators and life saving medical procedures unheard of in the 50's. The atom has been revealed as vastly more complex than anything I learned at school. What has been achieved in OOL research in that time? Nothing. Zero. And it never will be because the fundamental premise is flawed.