No problem there.
This is where AIG's logic goes bonkers, because it assumes that all four of these mutations have to occur in one specific individual, in one specific generation... all at the same time. And I'll admit, the odds of that happening are extremely low. But then again that's not what genetics says happens... so who cares.
What really happens is this ingenious thing that we call sex. Wherein 8 billion people run around swapping genes with each other,
and before you know it somebody who inherited one of these mutations from their parents, swaps genes with somebody who inherited a different one of these mutations from their parents. And for gosh sakes, now we've got people running around with two of these mutations. And sure as heck their offspring are gonna swap genes with somebody else's offspring. What is it with these people?
Don't they realize that if they keep doing this we'll soon have people with three mutations... and then heaven forbid... four, or five, or six, or God only knows how many.
But wait, what are the odds of somebody carrying each of these mutations? Well, not that bad actually. Remember those 8 billion people running around swapping genes? Well, along with the mutations that they got from their parents, they each got about 70 new mutations. That means that along with all the old mutations, each generation gets 560 billion new ones... in a genome that's only three billion letters long. So we've got a whole lot of repetition going on. Which means that the gene pool is constantly overflowing with mutations. So yeah, the odds that somebody with three of those mutations is unknowingly gonna swap genes with somebody with the fourth one, isn't really as far fetched as AIG makes it seem like it is.
But in any case, if you're really being honest with yourself... that 10^28 number is pure lunacy.