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You can start by understanding what spontaneous generation is.The difference is in name only I assure you
You can start by showing evidence that natural proteins are not naturally racemic.
Lies, Damned Lies, Statistics, and Probability of Abiogenesis CalculationsPut together all the essential DNA components in the proper concentrations and orientations and refresh them continuously. Provide wet and dry cycles and seed the mixture with tiny RNA and Protein segments catalyzed by enzymes. Provide a elemental sugar for fuel and expose the mixture to all wavelengths of light and polarizing radiation. Incubate it and cool it at regular intervals any way you like. Simulate great stretches of time by varying all the necessary parameters.
AND .. !no life will come fourth! Why? Because the science specifies the probability of life well below the universal bound. Simply (probability of life<< universal bound).
What, in your eyes, would constitute "scratching the surface on the origin of life problem"?Summary:
1. How close are scientists to creating life in the laboratory?
Scientists have not even begun to scratch the surface of the origin of life problem. It appears to be intractable.
I highly advise you to read the TalkOrigins article. Right now, it doesn't sound like you have.2. Best estimates of the probability that life arose spontaneously on the earth.
All calculations for the spontaneous origin of life give essentially zero chance, even in 10^9yrs.
You would do well to...3. Understand the problems
Um... wut?no such thing as a "simple" form of life
Monomers of what? Amino acids can. RNA bases can, IIRC. Adenine definitely, I think cytosine is a bit of a problem. Sugars can, though I seem to recall ribose is not the easiest to get. (But then, there are several possible alternatives to RNA as the first genetic material)monomers cannot be synthesized under prebiotic conditions
Far as I know, this is the biggest actual problem in your list. Unsurprisingly, we are not completely in the dark about possible solutions...origin of chemical chirality
Define "genetic information".origin of genetic information
Irreducible complexity is an empty buzzword, and this is sheer waffle.proteins/DNA/RNA - irreducible complexity
Douglas Theobald said:Only two basic steps are needed to gradually evolve an irreducibly complex system from a functioning precursor:
Add a part.
Make it necessary.
Stop confusing spontaneous generation with abiogenesis. After correcting your wording: the answer is yes. Brilliant scientists are allowed to have nutsy ideas, you know.4. Other naturalistic theories to explain life on earth?
Crick, Hoyle - panspermia or life seeded from outer space
(would brilliant scientists propose this if there was any hope at all for spontaneous generation?)
Such as?entirely different chemistry that evolved into the chemistry of life that exists today?
What on earth is wrong with that as a hypothesis? And what bearing does that have on abiogenesis?5. SETI / life on Mars?
naturalism - earth cannot be unique in the universe, therefore life must exist elsewhere
Holy ribosome, so none of the above "points" are even your own. I love how that page is still stuck in the mid-20th century with Miller-Urey. I love how they never bothered to update their information on RNA replication with, I don't know, this neat pair of indefinitely cross-replicating ribozymes, or this even neater one that can copy an arbitrary template up to 95 nucleotides long. (And I'm sure that number will increase further in the near future. It went from 14 to 95 in a decade...)
That IS the odds of the correct configuration.RMKQLEEKVYELLSKVACLEYEVARLKKVGE
The probability of generating this is successive random trials is (1/20)^32 or 1 chance in 4.29x10^40. This is much ,much more probable than the 1 in 2.04x10^390 of the standard creationist generating carboxypeptidase by chance scenario, but still seems absurdly low.
Lets make it lower Ian
Ian is not correct with the 4.29x10^40 nonsense.
His figure of 1/20^32 seems a bit optimistic since he is assuming only 20 amino acids to start with, actually there is more than 500 known natural amino acids. So the first correction that needs to be made is 1/500^32. The author still does not include the odds of forming the correct configuration of those amino acids (I will not include those either); the odds would be greatly decreased if you consider it.
Still rather greater than whatever times ten to the power of 390, and well within Dembski's nonsensical universal probability bound.*So the real calculation of the author must approach (1/500)^32=4.3^-87.
I don't know, but you certainly seem to trivialise him...Does Ian really want to trivialize statistics?
What is the relevance of this wall of text?Fair coin toss:
Now the probability of 4 heads in a row is is (1/2)4 or 1 chance in 16: do we have to do 16 trials to get 4 heads (HHHH)? No, in successive experiments I got 11, 10, 6, 16, 1, 5, and 3 trials before HHHH turned up.
Probability predicts that over a field of possible outcomes there is a desirable outcome. Ians example seems simple enough, but here is some perspective on outcomes and universal bounds. Lets, use one white marble and 15 black marbles (same odds as Ians). What are the odds of picking that one white marble out of a bag of 16 marbles and just one being white? Of course 1/16 right? That does not mean you can not pick the white marble the first time but only it is not the most likely outcome. Simply stated that out of 16 trials you are likely to pick the white marble (on average) once every 16 tries. Now lets see the odds of picking the white marble 16 times in a row. That is (.0625)^16 or 1/5.42x10^-20 (very small). Now lets look at really small possibilities, say picking a white marble out of a bag with 10^80 marbles, one being white. According to Borel that event would never happen, why? I will not go into his justification for Borels upper limit but I will try and put some perspective on it. In the observed universe it is estimated there are only 10^80 atoms. Say you could mark one atom ant throw it into the vastness of space. Now if you could pick from anywhere in the universe what are the odds of picking that marble the first time? 1 in 10^80th right. OK say you could pick one atom every second for several billion years longer than the age of the universe. How many atoms are left? Well about 10^80. In other words you did not discard enough atoms to affect the overall amount. So the last single choice would be for a volume of about 10^80th atoms or 1 chance in ten to the 80th. Sound reasonable? Well by Borels upper limit states that choice would not produce that single marked atom (no chance at all). I would have to agree with that conclusion. Where would you pick from? Maybe a hydrogen atom in the Crab Nebula?
doesn't mean as much as people think it does. In fact, in the majority of his trials, he got four heads in less than half the expected number of trials.you said:What are the odds of picking that one white marble out of a bag of 16 marbles and just one being white? Of course 1/16 right? That does not mean you can not pick the white marble the first time but only it is not the most likely outcome. Simply stated that out of 16 trials you are likely to pick the white marble (on average) once every 16 tries.
You see, he doesn't consider it because it's utterly irrelevant. You, on the other hand, didn't seem to consider this:You see Ians simplistic example does not consider a universal probability bound Borels or Dembskis.
TalkOrigins said:Yes, one kilogram of the amino acid arginine has 2.85 x 1024 molecules in it (that's well over a billion billion); a tonne of arginine has 2.85 x 1027 molecules. If you took a semi-trailer load of each amino acid and dumped it into a medium size lake, you would have enough molecules to generate our particular replicator in a few tens of years, given that you can make 55 amino acid long proteins in 1 to 2 weeks [14,16].
Last time I checked, it was earth...What planet do you live on?
Excuse me, but where the hell did you get that number?You keep proving you know nothing about probability. If you had the given amino 32 acids combined the probability of the order would be 32 ! = 2.63130837 × 10^35. My calculation for Ians mess is correct and concedes all possible allowances.
A significant subset of them probably would. But that's not really the question, isn't it? The Ghadiri peptide was taken as a concrete example to illustrate a principle (i.e. that the creationist probability calculations are calculating the wrong thing), and it just happens to be a replicator. But there is nothing to say that you need all 20 amino acids to get a replicating peptide, and in fact, peptides are probably irrelevant to the origin of self-replication anyway. (Try doing the numbers for the hexanucleotide replicator mentioned in the same article.)Do you really think that it is reasonable to assume that a collection of these 20 particular proteins are just floating around in a primordial soup?
"That" being...?That is one of the most fanciful, ridiculous postulations I have ever heard of.
It probably "knows" more than you do... I for one have no idea what you mean by "stuck in hopeless equilibrium from mass action". Maybe I didn't study enough chemistry, after all, I quit it after high school. Please explain?The only proteins formed would be racemic junk and stuck in a hopeless equilibrium from mass action.
Evolution knows nothing of natural chemistry
There is exactly an infinite (uncountably infinite, to be precise) number of numbers between 1 and 5. And what you're doing by limiting the choice to whole numbers is making the probability of picking any one number using an unbiased method finite, not making the choice meaningful. It also fails to relate to the concept of a universal probability bound in any way I can see. Are you saying that the universe has an infinite number of choices unless we arbitrarily limit the possibilities we consider? Because that's what your analogy says...First of all about the universal bound. Supposed I asked you to pick a number between 1 and 5. There is an almost an infinite amount of numbers between 1 and 5, say I picked 2.00009 or 4.1287. A bound on the numbers must exist to make the choice meaningful, say to actually define a probability of 1 in 5, you would place a restriction of whole numbers.
No, that is diametrically opposite to the whole concept of chance (i.e. you can never be certain about it). More to the point:The very same thing must be done with a limit that restricts probability that can actually happen within our know universe and time. Face it; if you cannot accept the universal bound just throw out probability all together. Because some probability just has no chance of ever coming up (that is just fact).
Let's pick whole numbers between 1 and 5, then. If I have n opportunities to pick, what's my chance of picking 5 somewhere along the line?
Since the chance of not picking 5 in any one trial is 1-(1/5) = 4/5, my chance of not picking 5 in n trials is (4/5)[sup]n[/sup]. The chance of picking 5 at least once out of n trials is therefore 1-((4/5)[sup]n[/sup]). If I'm given 5 attempts, same as the number of possibilities, that comes to about 2/3 (not close to 1 as I'd guessed). If I have to pick one number out of 10 rather than 5, and have 10 attempts to pick, my probability of bagging the right number decreases slightly, to about 65%. However, as I increase the number of choices, the probability seems to converge to somewhere around 63%. Unfortunately, I have no calculators capable of handling stupidly small numbers, so I couldn't actually get anywhere near 10[sup]80[/sup] choices.
Now, maths was a long time ago, so if anyone can confirm or refute that this probability converges rather than going to zero with an ever decreasing slope, I would be immensely grateful. Thus far, it seems that a 1 in [universal bound] event would have a very reasonable chance of occurring in this universe, if the universal bound represents the number of events that could have occurred.