Scientists have discovered why humans no longer have tails
The details:Around 25 million years ago, an evolutionary split occurred between our ancestors, the precursors of humans and apes, and monkeys, resulting in the loss of tails in our lineage. However, the genetic mutation responsible for this significant transformation has remained elusive until now.
In a new study published in Nature, researchers unveiled a unique DNA mutation linked to the disappearance of ancestral tails. This mutation resides within the TBXT gene, which plays a role in tail length regulation in tailed animals.
In the latest study, researchers identified two Alu elements within the TBXT gene exclusive to great apes, absent in monkeys. Interestingly, these elements reside in introns, sections of DNA flanking exons that were traditionally deemed non-functional "dark matter." However, when the TBXT gene produces RNA, the repetitive nature of Alu sequences causes them to bind together, resulting in the removal of an entire exon during RNA splicing.
Experimentation involving the introduction of these Alu elements {repetitive DNA sequences unique to primates, which can introduce variability by inserting themselves into the genome} into mice revealed a loss of tails, mirroring the evolutionary transition observed in humans and apes. Notably, this finding supports the hypothesis that tail loss facilitated the evolution of bipedalism in humans, a crucial adaptation.