My wife and I went to Niagara Falls last year around this time. On the way home, instead of using the turnpike to return home to Ohio, we followed NY 5 that runs along Lake Erie. We both enjoyed it very much, stopping in small towns like Dunkirk NY where we swam in the lake, etc.
I have always wanted to follow the road that runs along the Ohio River, so we did a 4 day road trip starting Friday of Labor Day weekend with the Indiana border (Lawerenceburg- and no, we did not go to the casino), stopping to visit the Creation Museum (in KY), since we visited the Ark about 4 years before that. I wasn't too impressed with the CM, although it draws a big crowd; they charge you $15 to park in their lot. Admission for seniors (over 60) is $45 each There's a lot of walking involved and my wife has a bad knee, I offered to rent her a scooter. Scooter rental is $38 She bravely opted to hoof it. The casino may have been a cheaper visit
We then went around Cincinnati via 275(our only interstate travel) and headed east on US 52 which is regarded by the state, and the USDOT as a scenic route- with a speed limit in some places, of 60MPH so the locals tailgate and get frustrated with you if you actually do use it as a scenic route. Point Pleasant, OH is one of the first points on the route, with Ulysses S Grant's birthplace on the street corner.
There is indeed some beautiful sights and interesting things along the way. Portsmouth OH has amazing murals painted along the flood walls . Point Pleasant, West Virginia has done the same.
We ended our trek in Gallipolis, OH because we had to head back Monday My stepdaughter has visited The Mothman Museum in Point Pleasant WV before, so we stopped in there before heading back. "Mothman", as I recently found out, is a type of Bigfoot for that area. They also had a lot of info on the Silver Bridge collapse in 1967 that was interesting. Overall, it was a fun place, the admission and the souvenir's were way cheaper than the Creation Museum's so we bought a Mothman fridge magnet for ourselves and my stepdaughter, as well as some Mothman Root Beer, for the trip home. we crossed the Silver Memorial Bridge, and headed home via US 35 which was also a nice ride home, some drivers notwithstanding.
Many people are not-so-courteous on the road I needed to get over where 35 splits off of US 23 to go to Columbus, I signaled, and a pickup truck behind me actually sped up to try to prevent me from getting a space in front of him. By the time the split happened, the truck was not even headed the way I was going- "Sheep without a shepherd". Matthew 9:36