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- What is Ozempic personality?
- Common Ozempic side effects
- How Ozempic affects the brain
- Can Ozempic cause personality changes?
- Does semaglutide affect mood
Doctors discuss drugs that lead to weight loss and personality changes.
- Some people taking drugs that lead to weight loss, like Ozempic, say the medication impacts their mood.
- This led to the term, “Ozempic personality,” which notes that these drugs may cause some to feel depressed and anxious.
- Doctors say they see this often in people who lose weight.
There’s been a lot of chatter over the past year about Ozempic and its impact on the body. While the semaglutide medication (the main active ingredient in Ozempic) is technically designed for blood sugar management in people with type 2 diabetes, it’s also used off-label for weight loss—and that’s only fueled its popularity.
With that, reports have swirled around online of people having unexpected side effects of taking Ozempic. The latest: Some say they’re experiencing mood changes in what’s now been dubbed “Ozempic personality.”
Several people online have opened up about going through personality changes. “I have minimal passion for anything, very monotone, and no enthusiasm,” one person wrote on Reddit. “I hear good news I respond with ‘okay.’ Things I enjoy seem to be a chore.” But another said that they feel more “calm” now that they’re on Ozempic. “I’m more optimistic about my future. More content with my present. But I know I both feel and appear calmer to others,” they said. “That might present as my being in a lower mood to some but I am not experiencing it like that.”
Continued below.

Reports of ‘Ozempic Personality’ Are Bubbling Up on Social Media—What to Know
This phenomenon is apparently common—and may affect mood.