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Cholesterol and fraud - Anthony Chaffee, MD
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<blockquote data-quote="timewerx" data-source="post: 77509302" data-attributes="member: 314730"><p>Exercising in fasted state and eating with restraint (as opposed to indulgence) would prevent problems you could have with high fat and high carb diet.</p><p></p><p>Animals who are very physically active like birds and bats also live on diets that combine high fat and high carbs. High-fat insects and high carb fruits are staple food for many species of omnivorous birds and bats. It's not a problem if energy demand is high.</p><p></p><p>Everyday, I do 1 hr of running with 1,000 ft of elevation gain. On Saturdays, it can be nearly 6 hrs nonstop cycling ride with 5,500 elevation gain in the mountains. I do these workouts without eating nor drinking without any problems. An impossible thing to do if your metabolism and mitochondria is impaired.</p><p></p><p>I didn't know about the Randle thing until you told me. The Holy Spirit is wise above all else. Holy Spirit told me many things to stay healthy but two things stood out which is exercise and fasting and combining those two - exercising in fasted state.</p><p></p><p><em><span style="color: rgb(184, 49, 47)"><strong>Flooding the system with glucose on top of fatty acids is expected to induce considerable damage to the mitochondria if energy demand is not concomitantly increased.</strong></span> <strong><span style="color: rgb(184, 49, 47)">An overabundant diet rich in carbohydrates and fat (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/#r184" target="_blank">184</a>) should force-feed electrons from glucose into the respiratory chain, in which the already prevailing high ΔΨ prevents electron flow.</span></strong> This excessive energy supply, not matched by energy demand, will further worsen the jamming of electrons in the respiratory chain and eventually result in massive ROS production and mitochondrial damage (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/figure/f7/" target="_blank">Fig. 7</a>). In addition, a saturated flux through the glycolytic pathway could result in an overflow into the hexosamine biosynthetic pathway leading to protein glycosylation by O-linked β-N-acetylglucosamine (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/#r67" target="_blank">67</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/#r106" target="_blank">106</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/#r192" target="_blank">192</a>). The persistent combination of these two effects probably explains glucose toxicity. <strong><span style="color: rgb(41, 105, 176)">By contrast, the beneficial effects of physical activity and muscle exercise could prevent mitochondrial damage by decreasing ΔΨ and favoring the overall oxidation of substrates to fulfill the increased energy demand.</span> </strong></em></p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/[/URL]</p></blockquote><p></p>
[QUOTE="timewerx, post: 77509302, member: 314730"] Exercising in fasted state and eating with restraint (as opposed to indulgence) would prevent problems you could have with high fat and high carb diet. Animals who are very physically active like birds and bats also live on diets that combine high fat and high carbs. High-fat insects and high carb fruits are staple food for many species of omnivorous birds and bats. It's not a problem if energy demand is high. Everyday, I do 1 hr of running with 1,000 ft of elevation gain. On Saturdays, it can be nearly 6 hrs nonstop cycling ride with 5,500 elevation gain in the mountains. I do these workouts without eating nor drinking without any problems. An impossible thing to do if your metabolism and mitochondria is impaired. I didn't know about the Randle thing until you told me. The Holy Spirit is wise above all else. Holy Spirit told me many things to stay healthy but two things stood out which is exercise and fasting and combining those two - exercising in fasted state. [I][COLOR=rgb(184, 49, 47)][B]Flooding the system with glucose on top of fatty acids is expected to induce considerable damage to the mitochondria if energy demand is not concomitantly increased.[/B][/COLOR] [B][COLOR=rgb(184, 49, 47)]An overabundant diet rich in carbohydrates and fat ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/#r184']184[/URL]) should force-feed electrons from glucose into the respiratory chain, in which the already prevailing high ΔΨ prevents electron flow.[/COLOR][/B] This excessive energy supply, not matched by energy demand, will further worsen the jamming of electrons in the respiratory chain and eventually result in massive ROS production and mitochondrial damage ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/figure/f7/']Fig. 7[/URL]). In addition, a saturated flux through the glycolytic pathway could result in an overflow into the hexosamine biosynthetic pathway leading to protein glycosylation by O-linked β-N-acetylglucosamine ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/#r67']67[/URL], [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/#r106']106[/URL], [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/#r192']192[/URL]). The persistent combination of these two effects probably explains glucose toxicity. [B][COLOR=rgb(41, 105, 176)]By contrast, the beneficial effects of physical activity and muscle exercise could prevent mitochondrial damage by decreasing ΔΨ and favoring the overall oxidation of substrates to fulfill the increased energy demand.[/COLOR] [/B][/I] [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/[/URL] [/QUOTE]
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